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  Explore the key aspects of FLT3m+ AML  
  AML is a heterogeneous, hematologic disease that arises from the rapid expansion of myeloid blasts in the bone marrow and peripheral blood of adult patients.1 FLT3 is the most commonly identified gene mutation in AML.2,3  
Deepen your knowledge of FLT3m+ AML at
AML=acute myeloid leukemia; FLT3=FMS-like tyrosine kinase 3; m+=mutation positive.
  References: 1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Acute Myeloid Leukemia Version 1.2018. © National Comprehensive Cancer
Network, Inc. 2018. All rights reserved. Accessed 02-19-2018. To view the most recent and complete version of the guideline, go online to 2. Patel JP, Gönen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012;366(12):1079-89. 3. Alvarado Y, Kantarjian HM, Luthra R, et al. Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3–tyrosine kinase domain mutations. Cancer 2014;120(14):2142-9.
  © 2018 Astellas Pharma US, Inc. All rights reserved. 077-0067-PM. 4/18  
  Astellas and the flying star logo are trademarks of Astellas Pharma Inc.  

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