TREATING WITH CURATIVE INTENT:
THE ROLE OF MULTIMODALITY
THERAPY IN STAGE III NSCLC
Dear Healthcare Provider,
AZIOinPractice.com is a new website that highlights best practices of treating patients with Stage III NSCLC with curative intent through a series of expert panel videos.1
Medical advances in the past 10 years in patients with Stage III NSCLC include:
These advances have helped oncologists refine patient prognosis and treatment for Stage III NSCLC. Curative intent is the goal of treatment in patients with Stage III NSCLC, so it is essential to evaluate each patient on a case-by-case basis.1
Concurrent chemoradiotherapy (cCRT) is the standard of care in treating patients with unresectable Stage III NSCLC.7
Multimodality therapy has been proven to improve outcomes in Stage III NSCLC7,8
Today, cCRT offers patients the potential for treatment with curative intent1
CRT: chemoradiation therapy; NSCLC: non-small cell lung cancer.
References: 1. Cheema PK, Rothenstein J, Melosky B, Brade A, Hirsh V. Perspectives on treatment advances for stage III locally advanced unresectable non-small-cell lung cancer. Curr Oncol. 2019;26(1):37-42. 2. Farjah F, Flum DR, Ramsey SD, Heagerty PJ, Symons RG, Wood DE. Multi-modality mediastinal staging for lung cancer among medicare beneficiaries. J Thorac Oncol. 2009;4(3):355-363. 3. Detterbeck FC, Boffa DJ, Kim AW, Tanoue LT. The eighth edition lung cancer stage classification. Chest. 2017;151(1):193-203. 4. Rami-Porta R, Asamura H, Travis WD, Rusch VW. Lung cancer—major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):138-155. 5. Santana-Davila R, Devisetty K, Szabo A, et al. Cisplatin and etoposide versus carboplatin and paclitaxel with concurrent radiotherapy for stage III non-small-cell lung cancer: an analysis of Veterans Health Administration data. J Clin Oncol. 2015;33(6):567-574. 6. Chan C, Lang S, Rowbottom C, Guckenberger M, Faivre-Finn C; IASLC Advanced Radiation Technology Committee. Intensity-modulated radiotherapy for lung cancer: current status and future developments. J Thorac Oncol. 2014;9(11):1598-1608. 7. Yoon SM, Shaikh T, Hallman M. Therapeutic management options for stage III non-small cell lung cancer. World J Clin Oncol. 2017;8(1):1-20.
8. Antonia SJ, Villegas A, Daniel D, et al. Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC. N Engl J Med. 2018;379(24):2342-2350.
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